Skin boosters in Seoul, explained product by product
Skin boosters are injectables spread in small amounts through the skin to improve its quality: smoothness, hydration and fine lines, rather than obvious volume. In Korea the main families are polynucleotides (Rejuran), PDLLA collagen stimulators (Juvelook) and hyaluronic acid products such as SKINVIVE. Each has its own licence, evidence and price, and this site sets them out side by side.
Written by the Seoul Skin Boosters editorial team and medically reviewed by a Korean Board-Certified Dermatologist (AAD International Fellow · ASLMS member). Last reviewed: .
Guides
Product index
Polynucleotide (PN)Rejuran
Rejuran is a Korean polynucleotide skin booster. Its variants (Healer, i, S, HB plus), MFDS licence, evidence, what a session involves and Seoul prices.
PDLLA with hyaluronic acidJuvelook
Juvelook is a Korean PDLLA and hyaluronic acid injectable. Juvelook vs Juvelook Volume, MFDS licence, evidence, safety and Seoul prices compared.
Cross-linked HA microdropletsSKINVIVE
SKINVIVE by JUVÉDERM is a hyaluronic acid microdroplet injectable with FDA premarket approval for cheeks and neck lines. Trial results, Korean licence, price.
Other boosters
Other skin boosters you may hear about in Korea: Profhilo, Elravie Re2O, the “Chanel injection” (NCTF 135 HA), Rejuran S and Rejuran i, compared.
What are skin boosters
What skin boosters are, the main types used in Korea (HA, polynucleotide, PDLLA and collagen stimulators), and how they differ from fillers and Botox.
How to choose
Compare Rejuran, Juvelook, Juvelook Volume, SKINVIVE, Sculptra, Profhilo and Re2O by material, licence, course and Seoul price, then choose by concern.
Articles
Reading listJuvelook vs Rejuran
Compare Juvelook’s PDLLA and hyaluronic acid with Rejuran’s polynucleotides, understand the evidence, and ask about variants, risks, course and total cost.
Juvelook vs exosomes
Juvelook is an MFDS-licensed PDLLA injectable; exosome products are mostly sold as cosmetics in Korea and none has FDA approval. How the two compare.
Sculptra vs Rejuran
Sculptra (PLLA) and Rejuran (polynucleotide) work differently. Compare what they treat, FDA and MFDS status, sessions, results, risks and Seoul cost.
Rejuran and the FDA
Does Rejuran have FDA approval? What the FDA databases show, Rejuran’s MFDS licence in Korea, its status in Japan, Saudi Arabia and Europe, and what it means.
What counts as a skin booster?
“Skin booster” is a trade term, not a regulatory category. Regulators file these products by material and use. Korea’s Ministry of Food and Drug Safety (MFDS) lists Rejuran, Juvelook and SKINVIVE as Class 4 tissue-repair materials in its medical device database (checked 18 October 2026), while the US FDA files SKINVIVE as a dermal implant for aesthetic use in its premarket approval record.
What unites them is the goal: smoother texture, more even hydration and softer fine lines, built up over one or more sessions. What separates them is the material, and the material decides how quickly results appear, how long they last, what they cost and which side effects to watch for.
Where should you start?
- How skin boosters differ from fillers and Botox
- Rejuran: the polynucleotide booster and its variants
- Juvelook and Juvelook Volume: PDLLA collagen boosters
- SKINVIVE: the hyaluronic acid microdroplet booster
- Profhilo, Elravie Re2O, the Chanel injection, Rejuran S and Rejuran i
- A side-by-side comparison to help you choose
What do regulators say about these products?
Rejuran and Juvelook hold Class 4 medical device licences from MFDS in Korea, and neither appears in the FDA’s device or drug databases. SKINVIVE holds FDA premarket approval for cheek smoothness (2023) and neck lines (2026) and is imported into Korea under its own MFDS licence. The full record for Rejuran, country by country, is in Rejuran and the FDA.
Exosome products are a separate story: the FDA says none has its approval, and in Korea exosome products for the skin are sold as cosmetics, a category defined by application to the body rather than injection. Juvelook vs exosomes explains the difference.
How long do skin booster results last?
It depends on the material. In the SKINVIVE cheek trial, response rates held steady through the six-month follow-up [1]. Collagen stimulators work more slowly but were followed for longer: in the Sculptra cheek-wrinkle trial, 71.6% of treated adults met the response goal at 12 months, against 26.1% of untreated controls [2]. Polynucleotide trials have mostly been shorter, so ask how often maintenance sessions are planned.
How are prices and sources handled here?
Prices on the product pages are the KRW ranges listed by Delight Dermatology Clinic in Seoul. Prices checked 2026-10-18; confirm at consultation. Studies come from PubMed and are checked for retractions; regulatory statements come from the FDA and MFDS databases, checked on the same date. More detail is on the about page.
References
Bibliographic records retrieved from PubMed (U.S. National Library of Medicine).
Alexiades M, Palm MD, Kaufman-Janette J, et al. A Randomized, Multicenter, Evaluator-blind Study to Evaluate the Safety and Effectiveness of VYC-12L Treatment for Skin Quality Improvements. Dermatol Surg. 2023;49(7):682-688.
PubMed: 37163665Fabi S, Hamilton T, LaTowsky B, et al. Effectiveness and Safety of Sculptra Poly-L-Lactic Acid Injectable Implant in the Correction of Cheek Wrinkles. J Drugs Dermatol. 2024;23(1):1297-1305.
PubMed: 38206151